Beyond Palliation: Therapeutic Applications Of 153Samarium-EDTMP
نویسندگان
چکیده
منابع مشابه
Beyond Palliation: Therapeutic Applications of 153Samarium-EDTMP
Primary and metastatic malignant bone lesions result in significant pain and disability in oncology patients. Targeted bone-seeking radioisotopes including 153Samarium ethylene-diamine-tetramethylene-phosphonic acid (153Sm-EDTMP) have been shown to effectively palliate bone pain, often when external beam radiotherapy (EBRT) is not feasible. However, recent evidence also suggests 153Sm-EDTMP has...
متن کاملSuperscan on both 99mTc-MDP and 153Samarium-EDTMP Bone Scans in a Patient with Breast Cancer
One month later the patient received 4.22 GBq (114 mCi) 153Samarium-EDTMP for palliation of severe bone pain. Post treatment, whole body 153Samarium scan was also a “superscan” showing very similar osseous metastases pattern to the 99mTc-MDP bone scan. Anterior and posterior whole body images 24 hours after intravenous administration of 153Sm-EDTMP demonstrate diffuse osseous metastases in a ve...
متن کاملComparative Therapeutic Efficacy of 153Sm-EDTMP and 177Lu-EDTMP for Bone Pain Palliation in Patients with Skeletal Metastases: Patients’ Pain Score Analysis and Personalized Dosimetry
INTRODUCTION The aim of the present study was to compare the therapeutic efficacy of 153Sm-EDTMP and 177Lu-EDTMP in pain palliation in cancer patients with skeletal metastases. MATERIALS AND METHODS Thirty patients (25 M:5 F, mean age: 66.0 ± 14.7 years) of breast/prostate cancer with documented skeletal metastases were recruited prospectively. Twenty patients were considered randomly for tre...
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Some 4 decades ago, the first thoracic transplant of the modern era was performed. It was a heart, it was carried out in South Africa and although it did not last long, it opened a new door for treating patients dying of advanced cardiopulmonary conditions. Also, possibly a new door towards immortality? Perhaps that first heart transplant was too daring for its time, as surely there were many u...
متن کاملProduction, Quality Control and Pharmacokinetic Studies of 177Lu-EDTMP for Human Bone Pain Palliation Therapy Trials
Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...
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ژورنال
عنوان ژورنال: Clinical & Experimental Pharmacology
سال: 2013
ISSN: 2161-1459
DOI: 10.4172/2161-1459.1000131